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KMID : 1145120180160020233
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Asian Journal of Beauty and Cosmetology
2018 Volume.16 No. 2 p.233 ~ p.242
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Anti-inflammatory Effect of Galium aparine Extract in RAW 264.7 Cells
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Shim Joong-Hyun
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Abstract
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Purpose: This study was performed to identify the skin anti-inflammatory effect of Galium aparine (GA) extract on RAW 264.7 cells.
Method: To investigate anti-inflammatory effects of GA on RAW 264.7 cells, we measured 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, cell viability, mRNA expressions, nitric oxide (NO), and prostaglandin E2 (PGE2) production.
Results: In this study, we elucidated anti-inflammatory effects of GA extract on interleukin 1α (IL1α), interleukin 1β (IL1β) interleukin 6 (IL6), and tumor necrosis factor α (TNFα) mRNA expression and NO production. Quantitative real-time polymerase chain reaction (qRT-PCR) showed that the GA extract decreased mRNA expression level of IL1α, IL1β, IL6, and TNFα and detection of NO and PGE2 also revealed that GA induces anti-inflammatory effects.
Conclusion: Therefore, we successfully identified the anti-inflammatory effect of GA extract, and this result showed that the GA extract can be a potent cosmetic ingredient for anti-inflammatory and atopic dermatitis. Based on this, we anticipate further studies on the GA extract to determine a mechanism for developing not only cosmetics but also healthcare food or medicines.
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KEYWORD
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Galium aparine, Radical scavenging, Anti-inflammatory, Nitric oxide, PGE2
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